Friday, January 31, 2020

Jack Nicklaus biography and he's impact on society Essay

Jack Nicklaus biography and he's impact on society - Essay Example The Introduction of tournaments like Jack Nicklaus International invitation has motivated golf lovers with different skill levels to participate and to enhance the popularity of the game. Nicklaus himself was the most dominant personality among the golfers of his generation who has taken efforts to bring the sport of golf to the forefront. Jack Nicklaus-The golf legend Jack Nicklaus was born in Ohio on 21st of January 1962 and he started playing gold at the age of ten and even at this stage he showed immense talent and the rise of a promising player was in progress even from his childhood. The world witnessed an irresistible growth of Nicklaus over the finest golf players like Arnold palmer, Lee Trevino, Johnny Miller and Tom Watson in the next three decades. Nicklaus had eighteen professional and two armature wins in his golf career along with nineteen second and nine third place finishes. He has been ranked among the top ten players in 73 majors which constitute almost half of the successive majors he participated. Only five golf players in the world hold the record to win all the four major titles and Nicklaus became successful in obtaining this glorious achievement (Mackintosh 163). It is better to have a look in to the achievements of Jack’s golf career in order to get a clear picture of his extra ordinary talent as a golf player. He won six masters title in 1963, 1965, 1966 1972, 1975 and 1986, five PGA Championships in1963, 1971, 1973, 1975 and 1980, three British Opens in 1966, 1970 and 1978, and four U S Opens in 1962, 1967, 1972 and 1980. These tournaments are considered to be the key ones of professional golf. Nicklaus is the only one to hold the record for three time wins of all these four major tournaments. The list of his victories is pretty long and apart from the major tournament victories he won seventy one PGA Tours and achieved fifty eight second and thirty six third places. He also won five World Series of Golf titles, six numbers of Australian Opens, six Rider Cup appearances and many more victories around the world. Jack Grout discovered the abilities of Nicklaus for the first time and he took Nicklaus to the Scioto Country Club in Columbus his performance was very well appreciated by Senead, the defending champion of that period. Bobby Johns a legendary golf player of the era had made comment on the talent of the fifteen year old Nicklaus as â€Å"he plays a game with which I am totally unfamiliar,† which shows the expectations that golfers had regarding the future of Nicklaus (Mackintosh 164). The determination and a genuine desire to strive towards perfection always prompted Jack Nicklaus to look introspectively and question whether â€Å"he was making the proper adjustments to correct his swing technique during rounds when his play was inconsistent† (Shaw 86). It was this dedication, sincerity and hard work that made him an unchallenged champion in golf. Nicklaus turned professional after his victory in the 1961 U S Armature championship. In the year 1962, Nicklaus won U S Open title which was the first achievement in his professional golf career and in 1963 he won the Masters title and became the first ever golfer to achieve a

Thursday, January 23, 2020

Patalogy of the Central Nevrvous System: Multiple Sclerosis Essay

Multiple Sclerosis: Pathology of the Central Nervous System Multiple Sclerosis is an autoimmune disease that commonly found in individuals between the ages of 20 and 40. While men with MS tend to have a faster progressing disease, women are more likely than men to develop it. MS comes in many forms due to the extent of the damage and the amount of lesions, along with how quickly it progresses. All of this collectively forms the MS community today and has resulted in new test methods and forms of treatment developed to both help relieve the symptoms and slow the progression of the disease. This research paper will go through what causes a person to develop MS, what is going on within the body that causes the symptoms people experience, both the objective and subjective findings of MS, as wells as pharmaceutical and natural treatment options. Pathophysiology Multiple Sclerosis is distinguished as a chronic autoimmune disease that results in the demyelination of the central nervous system. The ultimate problem is that myelin within the central nervous system becomes inflamed and scarred which has massive effects on the individual. Huether and McCance (2012) go into great detail about what Multiple Sclerosis is stating that it is a multifactorial disease, meaning that it results when a person is genetically prone to developing MS and then develops a virus in the nervous system. The demyelination and inflammation of the central nervous system is caused by plasma cells, B-lymphocytes, T-cells and proinflammatory cytokines and causes the scarring and the degeneration of axons, which is unfortunately irreversible. Aside from the central inflammation caused by the disease, there is also injury throughout the CNS that is classified as ... ...ve the symptoms associated with the disease. Other, natural options, for people include dietary changes, daily exercise, massage, and herbal remedies to name a few. There are still unknowns about MS, however, there have been great advancements in the diagnosing and treatment of multiple sclerosis that are helping individuals who have the disease every day. References Alnar, O. (2009). Treatment of Multiple Sclerosis. CNS and Neurological Disorders- Drug Targest, 8 (3), 167-174. Cantorna, M. (2006). Vitamin D and its Role in Immunology: Multiple Sclerosis and Inflammatory Bowel Disease. Progress in Biophysics and Molecular Biology, 92, (1), 60- 64. Huether, S. E., McCance, K. L. (2012). Understanding Pathophysiology. St. Louis, Missouri: Elsevier Inc. Wilson, S., Giddens, J. Health Assessment for Nursing Practice. St. Louis, Missouri: Elsevier Inc.

Wednesday, January 15, 2020

Patriots, Loyalist, and the Neutral Ones Stuck in the Middle

Patriots, Loyalist, and the Neutral Ones Stuck in the Middle Today’s America is known for many things; however, one of the things it is notorious for is being a free country. Becoming a free country did not come without many trials and tribulations. The freedom that the American people now have grown so accustomed to started with fierce opposition not only from Britain, but from many of the Englishmen who lived in American colonies. The people that supported Britain throughout the American Revolution are referred to as Loyalists.On the other side of the spectrum, the people that strongly opposed Britain’s rule and King George III are known as Patriots. Patriots fought against the acts that Britain wanted to enforce and believed the colonies should have independence from Britain. Last there were the people who were neutral. While the Patriots and Loyalists were large in numbers, those in the neutral party were the minority, often suffering hardship due to their stance.Al though the Patriots found unity in the beliefs they held towards Britain, they were a blend of people from many different backgrounds. Patriots were a blended group of people from different social classes, from farmers to lawyers. They did not all share the same education level or common interests. The Patriot party was not fueled by people who were seeking their own power just for the purpose of being free. They were a group of people who felt like Britain was unjust in their tactics of rule. During, and immediately after the military conflict, a ferment of ideas — argued and discussed by an assemblage of remarkable men whose likes have rarely been seen — produced an innovative combination of republicanism and federalism that would serve as a model form of government for humankind, offering fresh political opportunities. † (Cowley and Parker 2001) The Patriots were against what they felt was unfair taxation, which was the beginning foundation of â€Å"no taxati on without representation. Some Patriots felt that loyalty should still be in place towards King George III; however like those who didn’t express similar loyalties, they felt â€Å"that taxes should be regulated by their own legislatures, not by members of Parliament in Great Britain. † (Houghton Mifflin Harcourt 2011) One of their base core values was liberty. However the liberties they wanted or already had experienced, had been threatened by the Britain’s greed. They opposed being held to rules that were not put in place by the population majority.They felt it was only just that the people in the colonies have rules and regulations that they set instead of following everything that Britain desired. Patriots had an overall want for a common good. The poor people would not be held to things the rich would put in place, instead the people of the colonies would find a common unity to benefit all of its inhabitants. Loyalists were a party of people that would clo sely identify with today’s slogan â€Å"if it isn’t broke, why fix it†. Everyone living in the colonies had adhered to the rules and regulations set forth in Britain before and in their eyes, change was not necessary.Many lacked the desire to rear against a country with so much power. Unlike the Loyalists opposing group, the demographics were much more similar in those that followed the King. Money was a common factor for them and so was the responsibility of being a business owner. Many business owners had links to Britain that tied their livelihood in America to their loyalties they expressed for Britain. Many Loyalists had ties to Britain’s upper-class through marriage and other family. All factors that can solidify the stance many Loyalists chose.They also feared the upheaval that could arise without being under the control of Britain. They had no way of knowing their families would be safe or that their businesses would not be destroyed. They had no reason to be confident there worries might be unjustified when the Patriots resorted to violence. Britain wasn’t only safe because change is hard; Britain was safe because of the orderliness that they maintained. Loyalists also felt it was a moral issue to not be loyal to King George III.In their eyes, they did not have the power to choose and side when their moral beliefs told them their only option was to be loyal to the crown. Finally there was the group that did not take a solid stance on either side of the debate. The neutral party was not necessarily the easier side to be on though. They tried to keep more to themselves and not be as active as others did. They tried to maintain a low profile and stay out of the way. However, by not choosing to be on one side or the other they were looked at poorly by both Patriots and Loyalists.They continued business with Britain, and followed their own protocol they deemed appropriate for themselves. â€Å"Men of good will simply sho uld not rob and butcher one another, they believed, and many felt that the correct stance was to refrain if at all possible from any form of participation. † (Fellman 1990) Note that â€Å"if at all possible† was not always permitted. â€Å"Nearly half of all colonists did not want to take sides. They wanted to remain neutral in the conflict between the British and the Patriots. But they were forced to choose sided once the war began. (Todd 2001) Everyone living in the American colonies during the war felt the effects. Though not all wanted to be involved, nor did many feel the need to participate, it was unavoidable. Men, women, and children shed blood; there was no one who was not impacted. Being a Patriot, Loyalist, or a neutral party was based on differences varying from monetary and social class, right down to fear of change; however, there was no difference when comparing the high emotion and the impact experienced during the American War.Works Cited Cowley, Robe rt, and Geoffrey Parker. Reader's Companion to Military History. Wilmington: Houghton Mifflin Harcourt, 2001. Fellman, Michael. Inside War: The Guerrilla Conflict in Missouri During the American Civil War. Oxford University Press, 1990. Houghton Mifflin Harcourt. 2011. http://www. hmheducation. com/fl/pdf/resources/Grade5/T-5-1_SFLETG713311_TGL08. pdf (accessed September 14, 2012). Todd, Anne M. The Revolutionary War. Capstone, 2001.

Tuesday, January 7, 2020

Chemistry Nobel Prize Winners (1901 to Present)

Alfred Nobel was a Swedish chemist and the inventor of dynamite. Nobel recognized the destructive power of dynamite, but hoped that such power would lead to an end to warfare. However, dynamite was quickly exploited to develop newer, more deadly weapons. Not wanting to be remembered as the merchant of death, an epitaph given him by a French newspaper in a mistaken obituary, Nobel wrote his will such that it would establish prizes in physics, chemistry, physiology or medicine, literature, and peace to those who, during the preceding year, shall have conferred the greatest benefit on mankind. A sixth category, economics, was added in 1969. It took some time to implement Nobels wishes. The first Nobel prize was awarded in 1901, which was five years after Alfred Nobels death. Note that the Nobel prize can only be won by individuals, there can be no more than three winners in a given year, and money is split equally between multiple winners. Each winner gets a gold medal, a sum of money, and a diploma. Here is the list of the Nobel laureates in Chemistry: Nobel Prize in Chemistry Year Laureate Country Research 1901 Jacobus H. vant Hoff Netherlands Discovered laws of chemical dynamics and osmotic pressure in solutions 1902 Emil Hermann Fischer Germany Synthetic studies of sugar and purine groups 1903 Svante A. Arrhenius Sweden Theory of electrolytic dissociation 1904 Sir William Ramsay Great Britain Discovered the noble gases 1905 Adolf von Baeyer Germany Organic dyes and hydroaromatic compounds 1906 Henri Moissan France Studied and isolated the element fluorine 1907 Eduard Buchner Germany Biochemical studies, discovered fermentation without cells 1908 Sir Ernest Rutherford Great Britain Decay of the elements, chemistry of radioactive substances 1909 Wilhelm Ostwald Germany Catalysis, chemical equilibria, and reaction rates 1910 Otto Wallach Germany Alicyclic compounds 1911 Marie Curie Poland-France Discovered radium and polonium 1912 Victor GrignardPaul Sabatier FranceFrance Grignards reagentHydrogenation of organic compounds in the presence of finely divided metals 1913 Alfred Werner Switzerland Bonding relations of atoms in molecules (inorganic chemistry) 1914 Theodore W. Richards United States Determined atomic weights 1915 Richard M. Willsttter Germany Investigated plant pigments, particularly chlorophyll 1916 The prize money was allocated to the Special Fund of this prize section 1917 The prize money was allocated to the Special Fund of this prize section 1918 Fritz Haber Germany Synthesized ammonia from its elements 1919 The prize money was allocated to the Special Fund of this prize section 1920 Walther H. Nernst Germany Studies on thermodynamics 1921 Frederick Soddy Great Britain Chemistry of radioactive substances, occurrence and nature of the isotopes 1922 Francis William Aston Great Britain Discovered several isotopes, mass spectrograph 1923 Fritz Pregl Austria Microanalysis of organic compounds 1924 The prize money was allocated to the Special Fund of this prize section 1925 Richard A. Zsigmondy Germany, Austria Colloid chemistry (ultramicroscope) 1926 Theodor Svedberg Sweden Disperse systems (ultracentrifuge) 1927 Heinrich O. Wieland Germany Constitution of bile acids 1928 Adolf Otto Reinhold Windaus Germany Study of sterols and their relation with vitamins (vitamin D) 1929 Sir Arthur HardenHans von Euler-Chelpin Great BritainSweden, Germany Studied fermentation of sugars and enzymes 1930 Hans Fischer Germany Studied blood and plant pigments, synthesized hemin 1931 Friedrich BergiusKarl Bosch GermanyGermany Developed chemical high-pressure processes 1932 Irving Langmuir United States Surface chemistry 1933 The prize money was with 1/3 allocated to the Main Fund and with 2/3 to the Special Fund of this prize section. 1934 Harold Clayton Urey United States Discovery of heavy hydrogen (deuterium) 1935 Frederic Joliot-CurieIrne Joliot-Curie FranceFrance Syntheses of new radioactive elements (artificial radioactivity) 1936 Peter J. W. Debye Netherlands, Germany Studied dipole moments and the diffraction of X rays and electron beams by gases 1937 Walter N. HaworthPaul Karrer Great BritainSwitzerland Studied carbohydrates and vitamin CStudied carotenoids and flavins and vitamins A and B2 1938 Richard Kuhn Germany Studied carotenoids and vitamins 1939 Adolf F. J. ButenandtLavoslav Stjepan Ruika GermanySwitzerland Studies on sexual hormonesStudied polymethylenes and higher terpenes 1940 The prize money was with 1/3 allocated to the Main Fund and with 2/3 to the Special Fund of this prize section 1941 The prize money was with 1/3 allocated to the Main Fund and with 2/3 to the Special Fund of this prize section. 1942 The prize money was with 1/3 allocated to the Main Fund and with 2/3 to the Special Fund of this prize section. 1943 Georg de Hevesy Hungary Application of isotopes as indicators in the investigation of chemical processes 1944 Otto Hahn Germany Discovered nuclear fission of atoms 1945 Artturi Ilmari Virtanen Finland Discoveries in the area of agricultural and food chemistry, method of preservation of fodder 1946 James B. Sumner John H. Northrop Wendell M. Stanley United StatesUnited StatesUnited States Prepared enzymes and virus proteins in pure formCrystallizability of enzymes 1947 Sir Robert Robinson Great Britain Studied alkaloids 1948 Arne W. K. Tiselius Sweden Analysis using electrophoresis and adsorption, discoveries concerning serum proteins 1949 William F. Giauque United States Contributions to chemical thermodynamics, properties at extremely low temperatures (adiabatic demagnetization) 1950 Kurt AlderOtto P. H. Diels GermanyGermany Developed diene synthesis 1951 Edwin M. McMillanGlenn T. Seaborg United StatesUnited States Discoveries in the chemistry of transuranium elements 1952 Archer J. P. MartinRichard L. M. Synge Great BritainGreat Britain Invented distribution chromatography 1953 Hermann Staudinger Germany Discoveries in the area of macromolecular chemistry 1954 Linus C. Pauling United States Studied the nature of the chemical bond (molecular structure of proteins) 1955 Vincent du Vigneaud United States Synthesized a polypeptide hormone 1956 Sir Cyril Norman HinshelwoodNikolai N. Semenov Great BritainSoviet Union Mechanisms of chemical reactions 1957 Sir Alexander R. Todd Great Britain Studied nucleotides and their coenzymes 1958 Frederick Sanger Great Britain Structure of proteins, especially insulin 1959 Jaroslav Heyrovsk Czech Republic Polarography 1960 Willard F. Libby United States Application of carbon 14 for age determinations (radiocarbon dating) 1961 Melvin Calvin United States Studied the assimilation of carbonic acid by plants (photosynthesis) 1962 John C. KendrewMax F. Perutz Great BritainGreat Britain, Austria Studied the structures of globulin proteins 1963 Giulio NattaKarl Ziegler ItalyGermany Chemistry and technology of high polymers 1964 Dorothy Mary Crowfoot Hodgkin Great Britain Structure determination of biologically important substances by means of X rays 1965 Robert B. Woodward United States Syntheses of natural products 1966 Robert S. Mulliken United States Studied chemical bonds and the electron structure of molecules using the orbital method 1967 Manfred EigenRonald G. W. NorrishGeorge Porter GermanyGreat BritainGreat Britain Investigated extremely fast chemical reactions 1968 Lars Onsager United States, Norway Studied the thermodynamics of irreversible processes 1969 Derek H. R. BartonOdd Hassel Great BritainNorway Development of the concept of conformation 1970 Luis F. Leloir Argentina Discovery of sugar nucleotides and their role in the biosynthesis of carbohydrates 1971 Gerhard Herzberg Canada Electron structure and geometry of molecules, particularly of free radicals (molecular spectroscopy) 1972 Christian B. AnfinsenStanford MooreWilliam H. Stein United StatesUnited StatesUnited States Studied ribonuclease (Anfinsen)Studied the active center of ribonuclease (Moore Stein) 1973 Ernst Otto FischerGeoffrey Wilkinson GermanyGreat Britain Chemistry of metal-organic sandwich compounds 1974 Paul J. Flory United States Physical chemistry of macromolecules 1975 John CornforthVladimir Prelog Australia - Great BritainYugoslavia - Switzerland Stereochemistry of enzyme catalysis reactionsStudied the stereochemistry of organic molecules and reactions 1976 William N. Lipscomb United States Structure of boranes 1977 Ilya Prigogine Belgium Contributions to the thermodynamics of irreversible processes, particularly to the theory of dissipative structures 1978 Peter Mitchell Great Britain Studied biological energy transfer, development of the chemiosmotic theory 1979 Herbert C. BrownGeorg Wittig United StatesGermany Development of (organic) boron and phosphorous compounds 1980 Paul BergWalter GilbertFrederick Sanger United StatesUnited StatesGreat Britain Studied the biochemistry of nucleic acids, particularly hybrid DNA (technology of gene surgery) (Berg)Determined base sequences in nucleic acids (Gilbert Sanger) 1981 Kenichi FukuiRoald Hoffmann JapanUnited States Theories on the progress of chemical reactions (frontier orbital theory) 1982 Aaron Klug South Africa Developed crystallographic methods for the elucidation of biologically important nucleic acid protein complexes 1983 Henry Taube Canada Reaction mechanisms of electron transfer, especially with metal complexes 1984 Robert Bruce Merrifield United States Method for the preparation of peptides and proteins 1985 Herbert A. HauptmanJerome Karle United StatesUnited States Developed direct methods for the determination of crystal structures 1986 Dudley R. HerschbachYuan T. LeeJohn C. Polanyi United StatesUnited StatesCanada Dynamics of chemical elementary processes 1987 Donald James CramCharles J. PedersenJean-Marie Lehn United StatesUnited StatesFrance Development of molecules with structurally specific interaction of high selectivity 1988 Johann DeisenhoferRobert HuberHartmut Michel GermanyGermanyGermany Determined the three-dimensional structure of a photosynthetic reaction center 1989 Thomas Robert CechSidney Altman United StatesUnited States Discovered the catalytic properties of ribonucleic acid (RNA) 1990 Elias James Corey United States Developed novel methods for the synthesis of complex natural compounds (retrosynthetic analysis) 1991 Richard R. Ernst Switzerland Developed high resolution nuclear magnetic resonance spectroscopy (NMR) 1992 Rudolph A. Marcus Canada - United States Theories of electron transfer 1993 Kary B. MullisMichael Smith United StatesGreat Britain - Canada Invention of the polymerase chain reaction (PCR)Development of site specific mutagenesis 1994 George A. Olah United States Carbocations 1995 Paul CrutzenMario MolinaF. Sherwood Rowland NetherlandsMexico - United StatesUnited States Work in atmospheric chemistry, particularly concerning the formation and decomposition of ozone 1996 Harold W. KrotoRobert F. Curl, Jr.Richard E. Smalley Great BritainUnited StatesUnited States Discovered fullerenes 1997 Paul Delos BoyerJohn E. WalkerJens C. Skou United StatesGreat BritainDenmark Elucidated the enzymatic mechanism underlying the synthesis of adenosine triphosphate (ATP)first discovery of an ion-transporting enzyme, Na+, K+-ATPase 1998 Walter KohnJohn A. Pople United StatesGreat Britain Development of the density-functional theory (Kohn)Development of computational methods in quantum chemistry (GAUSSIAN computer programs) (Pope) 1999 Ahmed H. Zewail Egypt - United States Studied the transition states of chemical reactions using femtosecond spectroscopy 2000 Alan J. HeegerAlan G. MacDiarmidHideki Shirakawa United StatesUnited StatesJapan Discovered and developed conductive polymers 2001 William S. KnowlesRyoji NoyoriKarl Barry Sharpless United StatesJapanUnited States Work on chirally catalysed hydrogenation reactions (Knowles Noyori)Work on chirally catalysed oxidation reactions (Sharpless) 2002 John Bennett FennJokichi TakamineKurt Wthrich United StatesJapanSwitzerland Developed soft desorption ionisation methods for mass spectrometric analyses of biological macromolecules (Fenn Tanaka)Developed nuclear magnetic resonance spectroscopy for determining the three-dimensional structure of biological macromolecules in solution (Wthrich) 2003 Peter AgreRoderick MacKinnon United StatesUnited States Discovered water channels for transport of water in cell membranesPerformed structural and mechanistic studies of ion channels in cells 2004 Aaron CiechanoverAvaram HershkoIrwin Rose IsraelIsraelUnited States Discovered and elucidated the process of ubiquitin-mediated protein degradation 2005 Yves ChauvinRobert H. GrubbsRichard R. Schrock FranceUnited StatesUnited States Developed the metathesis method of organic synthesis, allowing for advances in green chemistry 2006 Roger D. Kornberg United States for his studies of the molecular basis of eukaryotic transcription 2007 Gerhard Ertl Germany for his studies of chemical processes on solid surfaces 2008 Shimomura OsamuMartin ChalfieRoger Y. Tsien United States for the discovery and development of the green fluorescent protein, GFP 2009 Venkatraman RamakrishnanThomas A. SteitzAda E. Yonath United KingdomUnited StatesIsreal for studies of the structure and function of the ribosome 2010 Ei-ichi NegishiAkira SuzukiRichard Heck JapanJapanUnited States for the development of palladium-catalyzed cross coupling 2011 Daniel Shechtman Israel for the discovery of quasi-crystals 2012 Robert Lefkowitz and Brian Kobilka United States for studies of G-protein-coupled receptors 2013 Martin Karplus, Michael Levitt, Arieh Warshel United States for the development of multiscale models for complex chemical systems 2014 Eric Betzig, Stefan W. Hell, William E. Moerner (USA) United States, Germany, United States for the development of super-resolved fluorescence microscopy 2016 Jean-Pierre Sauvage, Sir J. Fraser Stoddart, Bernard L. Feringa France, United States, Netherlands for the design and synthesis of molecular machines 2017 Jacques Dubochet, Joachim Frank, Richard Henderson Switzerland, United States, United Kingdom for developing cryo-electron microscopy for the high-resolution structure determination of biomolecules in solution